New Drug Development and Animal Experiments

New thinking on animal experiments

National regulations on animal experiments vary widely between countries but growing numbers of researchers in Britain believe that the procedures are in need of an overhaul. And a new report by a group of members of Britain’s upper house of parliament, the House of Lords, advises a shakeup that both speeds up consideration of researchers’ requests but opens up public scrutiny of such work. The...

Animal Models in Drug Development

Quality of Animal Experiments in Anti-Angiogenic Cancer Drug Development – A Systematic Review

Translation from preclinical animal research to clinical bedside has proven to be difficult to impossible in many fields of research (e.g. acute stroke, ALS and HIV vaccination development) with oncology showing particularly low translation rates (5% vs. 20% for cardiovascular diseases). Several investigations on published preclinical animal research have revealed that apart from plain species ...

Clumsiness and Disturbed Cerebellar Development: Insights From Animal Experiments

Cerebellar functioning has been implied in the fine adjustments of muscle tone, in the coordination and the feed-forward control of movements and posture, as well as in the establishment and performance of motor skills. The cerebellar cortex in mammals develops late in neuro-ontogeny and an extrapolation from experimental results indicates that in the human the proliferation of the granule cell...

Small animal imaging in drug development.

Better mechanistic understanding of disease through mapping of the human and mouse genomes enables rethinking of human infirmity. In the case of cancer, e.g., we may begin to associate disease states with their underlying genetic defects rather than with the organ system involved. That will enable more selective, nontoxic therapies in patients who are genetically predisposed to respond to them....